Computational Investigations for Undergraduate Organic Chemistry: Modeling Markovnikov and anti-Markovnikov Reactions for the Formation of Alkyl Halides and Alcohols

Rita K. Hessley

College of Applied Science, University of Cinncinati, Cinncinati, OH 45206

Abstract

Early in sophomore-level organic chemistry students are introduced to reaction mechanisms, and it is at this stage when they tend to become convinced that memorization is the skill they need to hone in order to succeed. This paper describes how the early introduction of molecular modeling for the study of reaction mechanisms leading to alcohols from alkenes can increase students' involvement in their own learning and can effectively challenge their misapprehension about memorization. It describes the use of modeling to emphasize structure-reactivity relationships rather than focusing on reagents, and tries to show that the use of molecular modeling is well suited for classroom and laboratory use as well as to assist students' study. Particularly in an educational setting that stresses collaborative or interactive learning, the methodology described here can be rewarding for teacher and student alike.

Journal of Chemical Education, 2000, 77, 794                       Full text (PDF)

-- SiripornJu - 08 Mar 2007